尹佳，教授、博导，德国德累斯顿工业大学博士。现任湖南省生物信息学会病原生物专委会副主委、省微生物学会常务理事，入选湖南省“杰青”与“湖湘青年英才”。长期聚焦畜禽饲用益生菌机制创新与产业化，先后主持国家自然科学基金（青年/面上）、国家重点研发计划子课题及企业横向等15项课题。以第一/通讯作者在 Nature Protocols、Microbiome、Gut Microbes 、Nucleic Acids Research、Trends in Biotechnology、Science China Materials等期刊发表论文40余篇；主编专著1部、合著2部；授权发明专利6项，其中4项已转化并落地产品3个。获农业部“神农中华农业科技奖一等奖”、省微生物学会“十佳青年科技奖”等荣誉。依托自主构建的高效微生物遗传操作系统，建立猪源母乳与肠道菌株资源库，解析抗氧化、抗炎症等功能机制，开发缓解断奶应激、降低腹泻率的微生态制剂，为“减抗替抗”和生猪产业高质量发展提供科技支撑。践行“以赛促学”，指导学生在全国大学生生命科学竞赛中屡获佳绩。
代表性论文（通讯作者*）：
Zheng Wentao, Yandong Xia, Xue Wang, Shiqing Gao, Diao Zhou, Vinothkannan Ravichandran, Chanjuan Jiang, Qiang Tu, Yulong Yin, Youming Zhang, Jun Fu*, Ruijuan Li*, Jia Yin*. Precise genome engineering in Pseudomonas using phage-encoded homologous recombination and the Cascade–Cas3 system [J]. Nature Protocols, 18(9): 2642-2670, 2023.
Zheng Wentao, Yandong Xia, Xue Wang, Shiqing Gao, Diao Zhou, Jun Fu*, Ruijuan Li*, Jia Yin*. Cascade-Cas3 facilitates high-accuracy genome engineering in Pseudomonas using phage-encoded homologous recombination [J]. Engineering Microbiology, 100046, 2022.
Yin Jia, Hongbo Zhu, Liqiu Xia, Xuezhi Ding, Thomas Hoffmann, Michael Hoffmann, Xiaoying Bian, Rolf Müller, Jun Fu, A Francis Stewart, Youming Zhang. A new recombineering system for Photorhabdus and Xenorhabdus [J]. Nucleic Acids Research, 43(6): e36, 2015.
Wang Leli, Qihang Liu, Yuwei Chen, Xinlei Zheng, Chuni Wang, Yining Qi, Yachao Dong, Yue Xiao, Cang Chen, Taohong Chen, Qiuyun Huang, Zongzhao Zhai, Cimin Long, Huansheng Yang, Jianzhong Li, Lei Wang, Gaihua Zhang, Peng Liao, Yong-Xin Liu, Peng Huang, Jialu Huang, Qiye Wang, Huanhuan Chu, Jia Yin*, Yulong Yin*. Antioxidant potential of Pediococcus pentosaceus strains from the sow milk bacterial collection in weaned piglets [J]. Microbiome, 10(1): 83, 2022.
Liu Yiting, Longjie Li, Jing Feng, Bing Wan, Qiang Tu, Wei Cai, Fa Jin, Guiying Tang, Lígia R. Rodrigues, Xiuwei Zhang*, Jia Yin*, Yunlei Zhang*. Modulation of chronic obstructive pulmonary disease progression by antioxidant metabolites from Pediococcus pentosaceus: enhancing gut probiotics abundance and the tryptophan-melatonin pathway [J]. Gut Microbes, 16(1): 2320283, 2024.
Li Rong, Shasha Chen, Xingang Zhang*, Fan Zeng, Xianyin Song, Jia Yin*, Changzhong Jiang*. Synergistic Photothermal Effect and Nanoenzyme for Efficient Antibacterial Activity [J]. Science China Materials, 67: 2985–2994, 2024.
Wang Leli, Vinothkannan Ravichandran, Yulong Yin, Jia Yin*, Youming Zhang*. Natural Products from Mammalian Gut Microbiota [J]. Trends in Biotechnology, 37(5): 492-504, 2019.
Gong Han, Yao Zeng, Shenghua Yang, Yan Gao, Mengjiao Luo, Manbo Zhang*, Yan Xu, Jia Yin*. Lipoic acid coated AgNPs incorporating with hydrogel for synergistic photodynamic/Ag+ bactericidal [J]. Materials Today Communications, 44: 112023, 2025.
Yin Jia, Wentao Zheng, Yunsheng Gao, Chanjuan Jiang, Hongbo Shi, Xiaotong Diao, Shanshan Li, Hanna Chen, Hailong Wang, Ruijuan Li, Aiying Li, Liqiu Xia, Yulong Yin, A. Francis Stewart, Youming Zhang, Jun Fu. Single-Stranded DNA-Binding Protein and Exogenous RecBCD Inhibitors Enhance Phage-Derived Homologous Recombination in Pseudomonas [J]. iScience, 14(1): 1-14, 2019.
Dong Yachao, Yandong Xia, Jie Yin, Diao Zhou, Yidan Sang, Sufeng Yan, Qingshu Liu, Yaqi Li, Leli Wang, Ying Zhao, Cang Chen, Qiuyun Huang, Ying Wang, Muhammad Nazeer Abbasi, Huansheng Yang, Chuni Wang, Jianzhong Li, Qiang Tu*, Jia Yin*. Optimization, Characteristics, and Functions of Alkaline Phosphatase From Escherichia coli [J]. Frontiers in Microbiology, 12(1): 761189, 2022.
Zhou Diao, Ying Zhao, Jing Li, Vinothkannan Ravichandran, Leli Wang, Qiuyun Huang, Cang Chen, Hengjia Ni*, Jia Yin*. Effects of Phytic Acid-Degrading Bacteria on Mineral Element Content in Mice [J]. Frontiers in Microbiology, 12(1): 753195, 2021.
Wang Leli, Yuwei Wu, Juan Xu, Qiuyun Huang, Ying Zhao, Sheng Dong, Xuxiang Wang, Xiaoni Cao, Chuni Wang, Anqi Wu, Diao Zhou, Cang Chen, Huansheng Yang, Jianzhong Li, Papadimitriou Konstantinos, Qiang Tu*, Gaihua Zhang*, Jia Yin*. Colicins of Escherichia coli Lead to Resistance against the Diarrhea-Causing Pathogen Enterotoxigenic E. coli in Pigs [J]. Microbiology Spectrum, 10(5): e01396-01322, 2022.
Yaling Hong, Chen Shasha, Li Mengyao, Li Wenhui, Gao Yan, Luo Mengjiao, Zhou Qian, Zhou Siyuan, Zhou Diao, Li Xinhui, Zhang Lei, Zhou Qiong, Yang Ziqiang, Xia Yandong, Zhang Gaihua*, Jia Yin*. Phosphate-solubilizing function of Pediococcus pentosaceus PSM16 and its underlying mechanism [J]. Microbiology Spectrum, 13(7): e00491-00425, 2025.
Zheng Wentao, Xue Wang, Yuwei Chen, Yachao Dong, Diao Zhou, Ruxin Liu, Haibo Zhou, Xiaoying Bian, Hailong Wang, Qiang Tu, Vinothkannan Ravichandran, Youming Zhang, Aiying Li*, Jun Fu*, Jia Yin*. Recombineering facilitates the discovery of natural product biosynthetic pathways in Pseudomonas parafulva [J]. Biotechnology Journal, 16(8): 2000575, 2021.
Yin Jia, Michael Hoffmann, Xiaoying Bian, Qiang Tu, Fu Yan, Liqiu Xia, Xuezhi Ding, A. Francis Stewart, Rolf Müller, Jun Fu, Youming Zhang. Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster from Streptomyces albus DSM41398 in Streptomyces coelicolor A3(2) [J]. Scientific Reports, 5(15081, 2015.
Yin Jia, Xuezhi Ding, Liqiu Xia, Ziquan Yu, Yuan Lv, Shengbiao Hu, Shaoya Huang, Zhenping Cao, Xiuqing Xiao. Transcription of gene in an acrystalliferous strain of Bacillus thuringiensis XBU001 positively regulated by the metalloprotease camelysin gene at the onset of stationary phase [J]. FEMS Microbiology Letters, 318(1): 92-100, 2011.
Wu Yuting, Feina Wu, Pan Zhao, Yan Gao, Mengyao Li, Mengjiao Luo, Qian Zhou, Siyuan Zhou, Xinhui Li, Yaling Hong, Yang Wu, Zhaorong Zhou, Yang Liu, Yandong Xia*, Lijun Zou*, Jia Yin*. Isolation and Mechanistic Investigation of the Efficient Zearalenone-Removing Strain Bacillus licheniformis YJ25 [J]. Toxins, 17(6): 263, 2025.
Wang Leli, Yiru Zhang, Juan Xu, Chuni Wang, Lanmei Yin, Qiang Tu*, Huansheng Yang*, Jia Yin*. Biosynthetic Gene Clusters from Swine Gut Microbiome [J]. Microorganisms, 11(2): 434, 2023.
Taohong Chen, Leli Wang, Qinxin Li, Yingjie Long, Yuming Lin, Jie Yin, Yan Zeng, Le Huang, Tingyu Yao, Muhammad Nazeer Abbasi, Huansheng Yang, Qiye Wang, Congjia Tang, Tahir Ali Khan, Qiuyue Liu, Jia Yin*, Qiang Tu*, Yulong Yin. Functional probiotics of lactic acid bacteria from Hu sheep milk [J]. BMC microbiology, 20(1): 228, 2020.
Guo Yao, Xiaohan Bian, Jiali Liu, Ming Zhu, Lin Li, Tingyu Yao, Congjia Tang, Vinothkannan Ravichandran, Peng Liao, Konstantinos Papadimitriou, Jia Yin*. Dietary Components, Microbial Metabolites and Human Health: Reading between the Lines [J]. Foods, 9(8): 1045, 2020.
课题组新闻：
尹佳课题组在细菌基因编辑和工程菌构建方面取得重要进展
印遇龙院士团队尹佳博士课题组在益生菌研究领域取得重要成果
尹佳副教授在国际著名期刊发表肠道菌群代谢物综述
尹佳博士团队在猪奶益生菌应用于人体健康方面被湖南卫视报道
养猪就是养肠道，养肠就用发酵饲料
科技成果转化公示——两项发明专利转让
“肠道健康才是真的健康”——尹佳做客第二十三期世承讲坛
邮箱：jiayin@hunnu.edu.cn
报考学科：生理学-分子调控与人体健康
研究方向：微生物-宿主相互作用
通讯地址：湖南师范大学生命科学学院3号楼A210
